Fig. 4.

Effect of PKC isoenzyme-specific inhibitors on levels of oxalate-induced cellular lipid hydroperoxide (LHP). LLC-PK₁ cells were pretreated with inhibitor peptide (2.5 μg/ml) or rottlerin (7.5 μM) for 30 min and then exposed to 0.75 mM oxalate along with inhibitors for 3 h, after which LHP was measured. DMSO was used as a vehicle. Data are normalized to control, and values are expressed as means ± SE. Comparisons shown: a, significant compared with control; b, significant compared with oxalate; c, significant compared with rottlerin-treated control; d, significant compared with inhibitor peptide-treated control. *P < 0.05; n = 6.