Fig. 10.

TDZD-8 treatment abolished the death-promoting effect of LY294002 and S3I201 in RPTC following oxidant injury. RPTC were treated with 1 mM H₂O₂ for 4 h in the absence or presence of LY29400 (20 μM) or S3I201 (50 μM) with/without TDZD-8 (40 μM). Cell viability was assessed by the MTT assay. Values are means ± SD of 3 independent experiments conducted in triplicates and expressed as the percentage of control. Bars with different letters are significantly different from one another (P < 0.05).