Fig. 4.

Mouse JAK2 JH2 domain. The amino acids comprising the JH2 domain are shown in black. Regions postulated to be important in the inhibition of JAK2 catalytic activity are highlighted. Highlighted in blue (from NH₂ to COOH terminus) are interface 1 and interface 2. Highlighted in yellow (from NH₂ to COOH terminus) are inhibitory regions (IR)1, 2, and 3. Tyr813, which is important in recruiting SH2B1, is highlighted in red. h, α-Helix; e, extended strand; t, β-turn; c, random coil. Analysis was by the secondary structure prediction method (SOPM) at http://npsa-pbil.ibcp.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_server.html (21a).