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Average cutaneous vasoconstriction (VC) in response to moderate whole body cooling (Tsk = 30.5°C; A) or norepinephrine (NE; 1 × 10−6; B) at each microdialysis site in young and older subjects. The %ΔCVCbaseline at control, fasudil (ROCK inhibited)-, NG-nitro-l-arginine methyl ester (l-NAME)-, and fasudil + l-NAME-pretreated sites (n = 16, 8 young and 8 older) subjects is shown. *P < 0.05 vs. control; †P < 0.05 vs. young; ‡P < 0.05 vs. l-NAME.
