Table 1.
Group means ± SE for absolute cutaneous vascular conductance
| Control | Fasudil | Fasudil + l-NAME | l-NAME | |
|---|---|---|---|---|
| Baseline | ||||
| Young | 0.29±0.06 | 1.60±0.24* | 1.28±0.24* | 0.22±0.04 |
| Older | 0.30±0.09 | 1.71±0.41* | 1.16±0.29* | 0.19±0.02 |
| Cooling | ||||
| Young | 0.19±0.05 (−34±3) | 1.16±0.20* (−30±5) | 0.89±0.16* (−28±4) | 0.14±0.02 (−38±4) |
| Older | 0.23±0.06 (−18±3) | 1.59±0.38*† (−7±1) | 1.01±0.25* (−11±4) | 0.15±0.02 (−23±4) |
| Rewarming | ||||
| Young | 0.30±0.06 | 1.31±0.27* | 0.95±0.17* | 0.20±0.04 |
| Older | 0.35±0.07 | 1.64±0.37*† | 1.07±0.32* | 0.20±0.02 |
| NE | ||||
| Young | 0.14±0.03 (−53±4) | 1.06±0.24* (−23±4) | 0.76±0.15* (−21±4) | 0.12±0.02 (−34±3) |
| Older | 0.18±0.03 (−41±9) | 1.52±0.36*† (−7±3) | 0.87±0.29* (−19±5) | 0.15±0.01 (−24±4) |
| SNP | ||||
| Young | 2.17±0.22 | 2.51±0.33* | 2.03±0.23 | 2.53±039* |
| Older | 2.86±0.43† | 2.49±0.47* | 2.31±0.44* | 2.65±036 |
Absolute cutaneous vascular conductance (CVC) values (laser-Doppler flux × mmHg−1) at baseline, maximal cooling (i.e., mean skin temperature = 30.5°C), precooling baseline following rewarming, norepinephrine (NE) perfusion, and sodium nitroprusside (SNP) perfusion are expressed as means ± SE for young (n = 8) and older (n = 8) subjects. Beside each CVC value for cooling and NE (in parentheses) are the corresponding relative values expressed as a percent change from baseline CVC.
*
P < 0.05 vs. control
†
P < 0.05 vs. young.