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Resistance to myocardial ischemia in hearts from BN/Mcw and SS/Mcw rats treated with SP and with 2,4-diamino-6-hydroxypyrimidine (DAHP). Isolated rat hearts were perfused with SP (50 μM; A) or DAHP (2.5 mM; B) for 40 min before 35 min global ischemia followed by 120 min reperfusion (Rep). s-dLVP, systolic-diastolic left ventricular pressure. Data are presented as means ± SD (n = 8–10/group). *P < 0.05 vs. SS/Mcw control group; #P < 0.05 vs. BN/Mcw control group.
