Table 1.

LV systolic function and hemodynamics

	NTg Sham	TgZ Sham	NTg Aortic Banded	TgZ Aortic Banded
LVEF, %	70±1.1	72±0.7	69±0.8	67±0.9
LV dP/dt, mmHg/s	7,756±443	8,000±328	9,659±714	8,798±518
LVSP, mmHg	92±2.3	91±2.3	168±5.5†	163±3.9†
MAP, mmHg	77±2.0	76±1.9	59±3.4†	63±1.9†
HR, beats/min	445±16	470±10	472±20	493±22
LVEDD, mm	3.56±0.07	3.64±0.04	3.56±0.04†	3.58±0.04
LV/BW	2.9±0.0	2.7±0.1	4.6±0.2†	3.5±0.1*†
Lung weight/BW	5.2±0.2	5.9±0.1	7.8±0.4†	6.7±0.2

Values are means ± SE; n = 10–18 mice. LV, left ventricular; NTg, nontransgenic; TgZ, transgenic mice overexpressing Zaki-4β; LVEF, LV ejection fraction; dP/dt, first derivitive of LV pressure; LVSP, LV systolic pressure; MAP, mean arterial pressure; HR, heart rate; LVEDD, LV end-diastolic dimension; BW, body weight.

^* P < 0.05, TgZ banded vs. NTg banded;

^† P < 0.05, aortic banded vs. sham operated.