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Schematic diagram of HGF-mediated inhibition of gluconeogenesis in primary hepatocytes. HGF signaling pathway activates AMPK signaling, leading to USF-1 activation via a DNA-PK-dependent pathway. USF-1 indirectly inhibits gluconeogenesis by binding to corepressor SHP gene promoter and induces SHP gene expression, which subsequently inhibits key gluconeogenic enzyme genes PEPCK and Glc-6-Pase (G6Pase) via inhibition of HNF4α and results in decreased gluconeogenesis.
