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Depiction of human PCSK9 promoter and its regulation by statin and BBR through the cis-regulatory elements and trans-acting factors. The plus sign indicates that statin induces SREBP2 to bind SRE-1 site of the PCSK9 promoter to stimulate transcription. The minus sign indicates the dual effects of BBR in reducing the binding of HNF1α to HNF1 site and the binding of SREBP2 to SRE-1 site.
