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. 2009 Aug 13;284(42):29065–29076. doi: 10.1074/jbc.M109.000638

FIGURE 1.

FIGURE 1.

PHD inhibition protects against MPTP-induced DAergic cell loss and striatal denervation. Male C57BL/6 mice were treated with 5% ethanol (EtOH) as a vehicle control or 100 mg/kg of DHB 6 h prior to saline (SAL) or 2 × 20 mg/kg of MPTP (intraperitoneally, 12 h apart). Mice were sacrificed 7 days post-MPTP and processed for various assays measuring nigrostriatal DAergic cell integrity. A, stereological quantification of TH-positive DAergic cell counts within the SN. *, p < 0.05 between EtOH/SAL and EtOH/MPTP; ⋀, p < 0.05 between DHB/SAL and DHB/MPTP; #, p < 0.05 between EtOH/MPTP and DHB/MPTP (mean ± S.E.; n = 4). B, quantification of TH immunoreactivity in striatum sections following treatments. *, p < 0.05 between EtOH/SAL and EtOH/MPTP; #, p < 0.05 between EtOH/MPTP and DHB/MPTP (mean ± S.E.; n = 3). C, neurochemical analysis of DA within ST terminals. *, p < 0.0001 between EtOH/SAL and EtOH/MPTP; ⋀, p < 0.0001 between DHB/SAL and DHB/MPTP; #, p < 0.0001 between EtOH/MPTP and DHB/MPTP (mean ± S.E.; n = 7).