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. 2009 Aug 13;284(42):29065–29076. doi: 10.1074/jbc.M109.000638

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — PHD inhibition by DHB attenuates MPTP-induced accumulation of nigrostriatal iron and decreases in ferroportin. A, nigral sections were used for Perls iron staining using 7% potassium ferrocyanide. B, striatal (STR) and cerebellar (CB) tissue were analyzed for total iron levels by ICP-MS (mean ± S.D.; n = 4). *, p < 0.05 between EtOH/SAL and EtOH/MPTP; #, p < 0.05 between EtOH/MPTP and DHB/MPTP. C, 7-μm paraffin-embedded sections of SN obtained from treated mice harvested at 24 h post-treatment were immunostained for ferroportin (green) and 4′,6-diamidino-2-phenylindole (blue).