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. 2009 Aug 13;284(42):29065–29076. doi: 10.1074/jbc.M109.000638

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — DHB prevents MPTP-mediated reduction in pyruvate dehydrogenase mRNA and activity levels. A, RT-PCR analysis of Pdh was performed on midbrain SN tissue obtained 12 h post-treatment; means ± S.D. are shown. EtOH/SAL (E/S), EtOH/MPTP (E/M), DHB/SAL (D/S), and DHB/MPTP (D/M). *, p < 0.05 significantly different from EtOH/SAL; ⋀, p < 0.05 significantly different from EtOH/MPTP (n = 4). B, PDH activity was measured in ST homogenates obtained 8 days post-treatment (means ± S.E.). *, p < 0.0001 between EtOH/SAL and EtOH/MPTP; #, p < 0.05 between EtOH/MPTP and DHB/MPTP (n = 3).