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The C and E domains of ADAM22. A, ribbons diagram of domain C showing that the HVR (pink) serves as a hat for domain C. The HVR is partially supported by two flap-like loops (in cyan and green). The wrist subdomain, referred to as Cw (26), is colored in slate. N, N terminus; C, C terminus. B, comparison of the ADAM22 domain C (cyan) with SVMPs (other colors) showing that the HVR harbors large variability. C, ribbons diagram of domain E of ADAM22.
