Skip to main content
. 2009 Jul 31;284(42):29136–29145. doi: 10.1074/jbc.M109.042333

FIGURE 2.

FIGURE 2.

BIM-46187 specifically inhibits heterotrimeric G protein downstream pathways. A, BIM-46187 inhibits the cyclic AMP accumulation in the MCF-7 cells treated with increasing concentrations of the G protein α subunit activator cholera toxin. B, BIM-46187 specifically inhibits the endothelin-induced calcium release in the A2058 cells without effects on the ionophore induced calcium release. C, BIM-46174 was ineffective to down-regulate the activation status of Rac1-GTP in human colon cancer cells HCT8/S11 cultured for 1 or 20 h in the presence of the G protein inhibitor. Similar data were obtained with BIM-46187 (1 mm, 10 min of incubation) in HCT8/S11 cells cultured under standard conditions. The data are representative of three separate experiments.