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. 2009 Dec 8;4(12):e8204. doi: 10.1371/journal.pone.0008204

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Geib, Hertel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The modified U7 snRNA contains a sequence complementary to the 3′ splice site of SMN exon 8. In addition, the wild-type murine U7 Sm binding sequence was replaced with the human consensus Sm binding sequence (SmOpt) to inactivate target cleavage [15]. (B) Nucleotide sequence and target location of the five different antisense oligonucleotides chosen for Adv-5 vector-derived delivery.