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. 2009 Dec 8;4(12):e8204. doi: 10.1371/journal.pone.0008204

Figure 3. Evaluation of endogenous SMN splicing patterns in SMA type I patient-derived fibroblasts.

Figure 3

SMA type I 3813 cells were transduced with Adv-5 vectors expressing antisense U7 snRNAs or control vectors (GFP, SmOpt) at a MOI of 20. Cells were passaged for 10 days in 2% FBS medium, and then harvested for RNA extraction. The bar graph gel image summarizes the levels observed from 8 independent experiments. Standard deviations are shown for each series. An asterisk above bars indicates a statistically significant difference between the experimental series and the SmOpt control series. A statistically significant difference between series is defined by p-values <0.005.