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The scavenger receptors CD36 and SR-A1 do not recognize HDL modified by the MPO/H2O2/Cl− system. Specific binding of HDL previously modified by the complete MPO/H2O2/Cl− system (oxHDL) to the indicated MPMs was determined as described under “Experimental Procedures.” Note that oxHDL binds equally well to wild type MPMs (A) and DKO MPMs (B). The results represent the means of triplicate determinations of a representative experiment performed at least three times.
