TABLE 1.
Mechanical measurements in isometrically contracted skinned TC fiber bundles from WT and NEB KO mice
Lines 1–5 were measured at pCa 4.3; lines 6 and 7 were measured at a pCa range of 8.5 to 4.3. NS means not significant.
WT | NEB KO | p value | |
---|---|---|---|
1. Tension (mN/mm2) | 84 ± 4 | 38 ± 2.2 | <0.001 |
2. Stiffness (mN/mm3) | 920 ± 23 | 388 ± 29 | <0.001 |
3. Tension/stiffness (0.01 mm) | 9.1 ± 0.4 | 9.7 ± 0.6 | NS |
4. ktr (s−1) | 7.8 ± 0.3 | 4.7 ± 0.3 | 0.003 |
5. Tension cost (pmol mN−1 mm−1 s−1) | 4.4 ± 0.3 | 5.9 ± 0.3 | 0.005 |
6. pCa50 | 5.90 ± 0.02 | 5.74 ± 0.01 | <0.001 |
7. nH | 4.38 ± 0.23 | 3.64 ± 0.14 | 0.02 |