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Proposed model for the IRES-mediated translation of SHMT1. In this model, an interaction between an ITAF bound to the 5′-UTR of the SHMT1 transcript and another ITAF bound to the 3′-UTR of the SHMT1 transcript serves to circularize the mRNA. This results in the formation of a closed loop similar to the one that is typically formed by the eIF4G/PABP/poly(A) tail interaction.
