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. 2009 Sep 15;284(45):31190–31199. doi: 10.1074/jbc.M109.057240

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 9. — A, kinetics of the oligomer to fibril transition of pre-fibrillar Hsp90-stabilized AS oligomers in the absence (■) and presence (●) of MgATP. B, effects of MgATP, AMPPNP, and 17-AAG on oligomer to fibril transition (t = 140 h). Measured values are averages including S.E. of three independent determinations. C, TEM image of pre-fibrillar AS oligomers generated by agitating an AS:Hsp90 solution for 1 week. D, amyloid fibrils obtained after MgATP was added to the same oligomeric solution.

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