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. 2009 Sep 15;284(45):31401–31411. doi: 10.1074/jbc.M109.033381

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Rat MAA (CI-α2 (22 kDa)) and EAAU. A, localization of MAA (CI-α2 (22 kDa)) and MMP-1 cleavage site on rat type I collagen α2 chain (Protein Data Bank code 1y0f) using UCSF Chimera software for molecular modeling. B, clinical course of EAAU induced by rat and bovine antigen. Data are presented as mean disease activity ± S.D. Histopathologic changes in the eyes of Lewis rats immunized with rat (C) and bovine (D) antigen. Note the heavy infiltration of inflammatory cells within the iris (I), the ciliary body (CB), and the anterior chamber (AC) at the peak of EAAU (day 19 postimmunization); however, cornea (Co) was not affected. E, EAAU did not develop in animals injected with adjuvant alone. Objective magnification was ×10.