TABLE 2.
Pathogenicity of MAA (CI-α2 (22kDa)) isolated from rat iris and ciliary body
| Antigen | Antigen dose | Adjuvant | EAAUa |
Day of onsetb | ||
|---|---|---|---|---|---|---|
| Incidence | Moderate | Severe | ||||
| μg | ||||||
| Rat MAA (CI-α2 (22 kDa)) | 50 | CFAc | 20/20 | 20/20 | 0 | 14 ± 0.5d |
| Bovine MAA (CI-α2 (22 kDa)) | 50 | CFA | 40/40 | 0 | 40/40 | 13 ± 1.0d |
| 0 | CFA | 0/20 | 0 | 0 | ||
| Intact α2 chain (rat iris/CB) | 50 | CFA | 0/20 | 0 | 0 | |
a The incidence of EAAU is given as positive/total eyes following clinical examination.
b Mean ± S.D. Severity of inflammation upon histopathologic examination was grouped as mild (1+), moderate (2+ to 3+), or severe (4+).
c CFA, complete Freund's adjuvant.
dp < 0.05.