FIGURE 6.

JNK inhibitor SP600125 blocks internalization of cross-linked CD36. A, RAW cells were treated without (inset) or with (main panel) SP600125 prior to cross-linking of CD36 and warmed with or without SP600125 present, and then fixed and imaged on a spinning disc confocal microscope. Scale bar, 10 μm. B, quantification of A. As in A, but with the addition of two acid wash steps before fixation. Images were acquired and quantified. Data are normalized to the untreated control and represent means ± S.E. of three experiments with at least 100 cells counted in each case.