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Inhibitors that block internalization of cross-linked CD36 also block oxidized LDL-dependent internalization of CD36. A, untreated RAW cells have internalized CD36 following incubation with nonlabeled oxLDL. Inset, no oxLDL added. B–F, RAW cells were pretreated with latrunculin B (B), SP600125 (C), PP1 (D), LY294002 (E), or amiloride (F) before incubation with nonlabeled oxLDL and stained for total CD36. Scale bar, 10 μm.
