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AMF-induced IL-8 plays a significant role in melanoma migration. The mean cell counts ± S.E. (n = 10) of migrating SBcl-2 and 1205Lu cells measured using a modified Boyden chamber assay are shown. A neutralizing antibody against IL-8 (20 μg/ml) and a control IgG antibody were included to determine the functional contributions of individual molecules to cell migration. *, p < 0.05 versus rAMF and IgG control antibody-treated cells.
