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. 2009 Sep 22;284(47):32413–32424. doi: 10.1074/jbc.M109.039891

FIGURE 3.

FIGURE 3.

Influence of TARP C-terminal chimeras with γ1 on the extent of desensitization of GluR1(Q)flip. A, typical current responses elicited by application of 300 μm glutamate in the absence and presence of 600 μm TCM of GluR(Q)flip alone and in coexpression with γ2, γ4, and their respective C-terminal chimeras with γ1 recorded in Xenopus oocytes. Black bars indicate duration of agonist application. B, IGlu+TCM/IGlu ratios for GluR1(Q)flip alone and in coexpression with wild-type and chimeric TARPs carrying the CTD of γ1 were calculated for each oocyte and averaged (±S.E.; ***p < 0.005 significantly different from GluR1(Q)flip alone; °°°, p < 0.005 significantly different compared with wild-type TARPs; Student's t test; n = 13–18 oocytes).