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. 2009 Sep 22;284(47):32413–32424. doi: 10.1074/jbc.M109.039891

FIGURE 4.

FIGURE 4.

Patch clamp analysis of desensitization kinetics of GluR1(Q)flip coexpressed with γ3 and chimeric γ3 carrying the CTD of γ1. A, glutamate-induced (3 mm) whole cell responses of GluR1(Q)flip in the absence and presence of γ3 and the γ3/γ1 chimera. The current responses are normalized and aligned to the peak current. B, extent of desensitization of GluR1(Q)flip during coexpression of either γ3 or the γ3/γ1 chimera. C, desensitization time constants of GluR1(Q)flip during coexpression of γ3 and the γ3/γ1 chimera. Bars represent means ± S.E. (n = 5 - 14; *, p < 0.05; ***, p < 0.005 significantly different from GluR1(Q)flip alone; °, p < 0.05; °°°, p < 0.005 significantly different compared with wild-type γ3; Student's t-test; n = 5–14).