. 2009 Sep 22;284(47):32413–32424. doi: 10.1074/jbc.M109.039891

TABLE 4.

Modulatory effects on AMPA receptor antagonist action of wild-type and chimeric TARPs carrying the C-terminal domain of γ1

Mean (±S.E.) glutamate (300 μm)-, CNQX (10 μm)-, DNQX (10 μm)-, and NBQX (10 μm)-induced current responses of GluR1(Q)flip in the absence and presence of each of the four original TARPs and the TARP-(CT)γ1 chimeras are shown.

	I_Glu (n)	I_CNQX (n)	I_DNQX (n)	I_NBQX (n)	I_CNQX+TCM (n)
	nA
GluR1(Q)flip	52 ± 8 (12)	0 ± 0 (14)	1 ± 0 (11)	1 ± 1 (12)	8.8 ± 2.1 (7)
+ γ1	43 ± 8 (10)	0 ± 0 (14)	1 ± 0 (10)	0 ± 0 (10)	6.3 ± 1.4 (7)
+ γ2	2603 ± 390 (13)^a	239 ± 55 (14)^a	134 ± 40 (12)^a	−382 ± 111 (13)^a	3506 ± 292 (10)^a
+ γ2-(CT)γ1	85 ± 19 (15)^b	1 ± 1 (18)^b	2 ± 1 (12)^b	−7 ± 3 (15)^b,c	30.8 ± 12.2 (8)^b
+ γ3	1282 ± 122 (14)^a	48 ± 7 (14)^a	24 ± 7 (13)^a	−76 ± 13 (14)^a	1280 ± 122 (9)^a
+ γ3-(CT)γ1	93 ± 17 (14)^b	1 ± 1 (17)^b	1 ± 0 (14)^b	−1 ± 1 (14)^b	13.0 ± 4.2 (14)^b
+ γ4	4267 ± 350 (10)^a	122 ± 25 (10)^a	58 ± 16 (9)^a	−281 ± 98 (10)^a	3258 ± 408 (10)^a
+ γ4-(CT)γ1	2571 ± 319 (10)^b	25.4 ± 8.9 (18)^a,b	32 ± 11 (8)^c	−83 ± 23 (10)^c	1401 ± 299 (13)^a,b
+ γ8	3795 ± 701 (10)^a	46 ± 13 (10)^a	22 ± 5 (9)^a	−105 ± 38 (9)^a	2241 ± 539 (9)^a
+ γ8-(CT)γ1	113 ± 13 (15)^b	1 ± 1 (18)^b	1 ± 1 (14)^b	−4 ± 1 (15)^b,d	23.5 ± 5.6 (13)^b

^a p < 0.005, significantly different compared with GluR1(Q)flip alone.

^b p < 0.005, significantly different from wild-type TARPs.

^c p < 0.01, significantly different compared with GluR1(Q)flip alone.

^d p < 0.05, significantly different compared with GluR1(Q)flip alone.