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Apoptosome formation using recycled Apaf-1. Recycled ADP-bound Apaf-1 remains in the monomeric state if no cofactors are supplied (black curve) or if only cytochrome c is added (yellow curve). As naive Apaf-1, recycled ADP-bound Apaf-1 requires both exogenous ATP and cytochrome c for apoptosome formation (blue curve). On the other hand, recycled AppNHp-bound Apaf-1 only requires cytochrome c for apoptosome formation (pink curve). mAU, milliabsorbance units.
