Figure 1.

Receptor binding autoradiography of normal and R6/2 mice brains. Representative coronal sections of control (A, C, and E) and transgenic R6/2 mouse brain hemispheres (B, D, and F) subjected to [³H]AMPA binding (A and B), [³H]QNB binding for muscarinic acetylcholine receptors (C and D), or [³H]SCH-23390 binding for D₁-like receptors (E and F). With all ligands, the R6/2 mice have lower levels of binding, but the extent of receptor binding decrease varies greatly, with D₁ DARs most affected, mAChRs somewhat less affected, and AMPA subtype of ionotropic GluR only slightly decreased.