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Study-specific (squares) and meta-analysis (diamond) odds ratios for colorectal cancer among persons with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype—TT versus CC. Meta-analysis estimate for the TT genotype versus the CC genotype: P < 0.001; Q = 37.602; P = 0.106; I2 = 26%, 95% confidence interval (CI): 0, 53. Horizontal lines, 95% CI.
