Table 6.

Pooled Analysis Odds Ratios for Colorectal Cancer Risk Among Persons With the Methylenetetrahydrofolate Reductase (MTHFR) 677TT Genotype, by Alcohol Consumption^a

Alcohol Consumption	No. of Subjects	CC		CT		TT		CT vs. CC		TT vs. CC
		No.	%	No.	%	No.	%	ORb	95% CI	ORb	95% CI
Never drinker	4,071
Controls		1,295	48.90	1,019	38.48	334	12.61
Cases		681	47.86	586	41.18	156	10.96	1.11	0.96, 1.29	0.93	0.74, 1.16
Ever drinker	5,657
Controls		1,502	43.68	1,477	42.95	460	13.38
Cases		1,023	46.12	941	42.43	254	11.45	0.89	0.79, 1.00	0.78	0.65, 0.93

Abbreviations: CI, confidence interval; OR, odds ratio.

^aUnadjusted P value for interaction between alcohol use and MTHFR genotype: P = 0.23. Wald χ² test (2 df) P value, by alcohol consumption: never drinker—P = 0.17; ever drinker—P = 0.0129.

^bAdjusted for age, sex, study, and ethnic group.