Table 2.
Patient characteristics at time of enrolment (ITT population). The differences between the treatmen groups were not statistically significant
| Characteristic | Nervoheel N (n = 136) | Lorazepam (n = 112) | P-value for difference (after propensity-score adjustment) |
|---|---|---|---|
| Age years | ≥0.05 | ||
| Mean (SD) | 45.1 (17.3) | 53.5 (16.6) | |
| Median | 44.0 | 54.0 | |
| 1st quartile-3rd quartile | 33.0–58.0 | 40.0–65.0 | |
| Female sex n (%) | 85 (62.5%) | 64 (57.1%) | ≥0.05 |
| Height cm (SD) | 167.6 (9.2) | 169.9 (8.7) | ≥0.05 |
| BMI kg/cm2 (SD) | 25.0 (4.4) | 24.7 (4.0) | ≥0.05 |
| Smoker n (%) | 32 (23.5%) | 33 (29.5%) | ≥0.05 |
| Regular use of coffee n (%) | 73 (53.7%) | 75 (67.0%) | ≥0.05 |
| Regular use of alcohol n (%) | 24 (17.6%) | 37 (33.0%) | ≥0.05 |
| Most common types of nervous disorder (%) (multiple entries possible) | ≥0.05 | ||
| Emotional distress | 77 (56.6%) | 61 (54.5%) | |
| Jitteriness | 76 (55.9%) | 64 (57.1%) | |
| Anxiety | 53 (39.0%) | 49 (43.8%) | |
| Psychological | 38 (27.9%) | 33 (29.5%) | |
| strain | 34 (25.0%) | 32 (28.6%) | |
| Agitation | 18 (13.2%) | 14 (12.5%) | |
| Burnout | |||
| Severity of symptoms | ≥0.05 | ||
| Mild | 35 (25.7%) | 17 (15.2%) | |
| Moderate | 76 (55.9%) | 67 (59.8%) | |
| Severe | 23 (16.9%) | 26 (23.2%) | |
| Baseline score of variables ±SD | ≥0.05 | ||
| Headache | 0.9 ± 0.8 | 0.9 ± 0.8 | |
| Heart palpitations | 0.6 ± 0.7 | 0.9 ± 0.9 | |
| Backache | 0.5 ± 0.7 | 0.5 ± 0.7 | |
| Indigestion | 0.7 ± 0.8 | 0.5 ± 0.6 | |
| Lack of appetite | 0.8 ± 0.8 | 0.7 ± 0.8 | |
| Mild sexual dysfunction | 0.8 ± 1.1 | 0.8 ± 0.9 | |
| Fatigue | 1.2 ± 0.8 | 1.0 ± 0.9 | |
| Listlessness | 1.3 ± 0.8 | 1.0 ± 0.8 | |
| Sleep disturbances | 1.6 ± 0.9 | 1.7 ± 0.9 | |
| Restlessness | 1.2 ± 0.8 | 1.3 ± 0.9 | |
| Lack of concentration | 1.3 ± 0.8 | 1.3 ± 0.9 | |
| Overall score | 10.8 ± 5.2 | 10.4 ± 5.7 |