Figure 2.

10HDA prevented VEGF-induced cell proliferation in HUVECs. HUVECs were incubated with the indicated concentrations of 10HDA in the presence or absence of VEGF (10 ng/ml) for 3 days at 37°C in 5% CO₂ with humidity. Cell proliferation was estimated using a CCK-8. VEGF treatments increased cell viability 2-fold (vs. control). 10HDA at 500 µM had no effect by itself, yet inhibited VEGF-induced proliferation. Data represent means and standard error (n = 6). ***P < 0.01 vs. control, **P < 0.01 vs. vehicle (Student's t-test).