Table 1.
FISH results according to UCCC criteria and 7q31 control
| Case N° |
EGFR/CEP7 Ratio | EGFR/NUCLEI Ratio (Range) | CEP7/NUCLEI Ratio(Range) | % of cells with >4 EGFR copies | NOTES | RESULTS (UCCC criteria) | 7q31/NUCLEI Ratio (Range) | CEP7/NUCLEI Ratio (Range) | RESULTS (7q31 control) |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 1.13 | 5.35 (3-8) | 4.7 (2-8) | 85% | P | 2.02 (1-4) | 4 (2-8) | P | |
| 2 | 1.50 | 8.4 (4-17) | 5.55 (2-10) | 100% | 10% of cells with >15 EGFR copies | A | 8.58 (4-14) | 7.2 (2-13) | P |
| 3 | 1.09 | 4.48 (3-9) | 4.1 (2-9) | 89% | P | 3.97 (2-5) | 4.8 (2-7) | P | |
| 4 | 2.80 | 12.42 (5-23) | 4 (2-7) | 100% | EGFR/CEP7 Ratio >2 | A | 2(2) | 5.3 (4-8) | A |
| 5 | 1.50 | 7.4 (3-16) | 4.9 (2-8) | 100% | 22,5% of cells with tight gene clusters | A | 4.48 (2-9) | 4 (2-7) | A |
| 6 | 1.45 | 6.2 (3-12) | 4.2 (2-8) | 84% | P | 4.44 (3-7) | 4.72 (2-7) | P | |
| 7 | 1.0 | 15.2 (10-40) | 14.5 (8-35) | 100% | 80% of cells with >15 EGFR copies | A | 1.70 | 18 (12-45) | A |
| 8 | 1.16 | 5.58 (3-10) | 4.78 (3-9) | 97% | P | 2.37 (1-4) | 5.2 (4-10) | P | |
| 9 | 1.05 | 4.92 (2-11) | 4.64 (2-9) | 82% | P | 5.07 (2-9) | 6.7 (2-11) | P | |
| 10 | 1.69 | 8.52 (4-22) | 5.04 (2-9) | 97% | 2.4% of cells with >15 EGFR copies | P | 2.2 (1-4) | 5 (2-12) | A |
| 11 | 1.24 | 4.89 (2-10) | 3.93 (2-8) | 75% | P | 6.07 (3-12) | 6 (2-10) | P | |
| 12 | 1.32 | 7.96 (3-15) | 6.01 (3-9) | 97% | 2,7% of cells with >15 EGFR copies | P | 3.2 (1-6) | 6 (3-10) | P |
| 13 | 1.25 | 10.5 (4-26) | 8.36 (4-23) | 100% | 16% of cells with >15 EGFR copies | A | 2.6 (2-5) | 7.7 (4-18) | A |
| 14 | 1.06 | 5.95 (2-13) | 5.6 (2-12) | 100% | P | 4.1 (2-5) | 6.3 (2-11) | P | |
| 15 | 1.18 | 4.39 (2-13) | 3.72 (1-13) | 72% | P | 3.36(2-5) | 3.9 (2-10) | P | |
| 16 | 1.22 | 4.64 (2-9) | 3.78 (2-6) | 71% | P | 2.35 (1-3) | 4.2 (2-7) | P | |
| 17 | 1.70 | 3.9 (1-8) | 2.2 (1-5) | 55% | P | 2.24 (1-4) | 3 (2-6) | P | |
| 18 | 1.10 | 4.9 (2-8) | 4.4 (2-7) | 90% | P | 6.02 (4-9) | 7.4 (2-10) | P | |
| 19 | 1.40 | 6.4 (3-23) | 4.7 (1-10) | 93% | Tight gene clusters in 11,5% of cells | A | 4.15 (2-7) | 5.6 (2-10) | A |
| 20 | 2.90 | 8.8 (2-13) | 3.1 (2-6) | 88% | EGFR/CEP7 Ratio >2 | A | 1.6 (1-3) | 2.1 (2-5) | A |
A = Amplification; P = Polysomy