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. 2009 Jul 9;284(36):23912–23924. doi: 10.1074/jbc.M109.036483

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 10. — Proposed mechanism of TGF-β1-mediated ZEBRA expression. Canonical (implicating Smad3) as well as noncanonical (implicating PI3-K/Akt) pathways, in concert, contribute to TGF-β1-mediated ZEBRA expression. TGF-β1 mediates its activity through binding to its receptor II which recruits and phosphorylates its receptor I/ALK5; Smad3 phosphorylation takes place and translocation to the nucleus occurs. However, activated Akt, the non-Smad mediator of TGF-β1 directed CBP-Smad3 interaction and Smad3 acetylation, which enables the increase of ZEBRA expression.