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Proposed sites of action of PKA and PP2B in regulating apoE transport and secretion. PKA inhibition with H89 inhibits apoE secretion without affecting apoE degradation and increases the size of the stable pool of cellular apoE, most likely acting on post-Golgi vesicular transport. In contrast, inhibition of PP2B with CsA inhibits both degradation and secretion of apoE, consistent with upstream accumulation of apoE in the ER compartment.
