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Compound 11 harbored in the pockets of ADAMTS-5 and MMP-13. a, direct superposition of ADAMTS-5 (green) and MMP-13 (PDB code 830c) reveals that compound 11 will clash with Phe244 in MMP-13 (purple). b, modeling based on other similar in-house structures shows that compound 11 can release from the close contact with Phe244, but generates a more serious clash with the carbonyl backbone of Phe241.
