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. 2009 Jun 25;284(36):24242–24256. doi: 10.1074/jbc.M109.014498

FIGURE 2.

FIGURE 2.

Pairwise interactions within the MLL1 core complex. a, summary of pairwise interactions that could be observed by sedimentation velocity analytical ultracentrifugation. (+) interaction detected; (−) no interaction detected. b–e, c(s) distributions of sedimentation velocity data of binary complexes at the following concentrations: 7 μm (solid black line), 3.5 μm (dashed line), and 1.5 μm (dotted line). b, MLL3745-WDR5 (reproduced from Ref. 45). c, WDR5-RbBP5; d, RbBP5-Ash2l; and e, Ash2L-DPY-30. f, schematic model summarizing the observed pairwise interactions and dissociation constants (Kd) within the MLL1 core complex.