TABLE 1.

Functional enrichment analysis

REGULATED
Clusters	Functional categories	No. of genes	Enrichment p values
1	Steroid metabolism	3	9.4E-003
5	Unfolded protein binding	12	1.5E-009
	Heat shock	7	5.9E-009
	Protein folding	12	1.5E-008
	Chaperone	10	1.6E-008
	Response to unfolded protein	7	2.2E-007
	Response to chemical stimulus	9	2.0E-005
6	Metal thiolate cluster	6	1.2E-011
	Heavy metal binding	5	7.1E-010
	Copper ion binding	5	1.4E-006
10	Amine metabolism	16	2.0E-008
	Amino acid metabolism	13	1.4E-007
	Endoplasmic reticulum	14	6.0E-005
	Endoplasmic reticulum membrane	6	6.3E-004
13	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism	23	4.1E-005
	Regulation of transcription	22	9.9E-005

DIFFERENTIALLY REGULATED
Clusters	Functional categories	No. of genes	Enrichment p values
1	Chaperone	14	1.7E-010
	Unfolded protein binding	16	5.1E-010
	Heavy metal binding	5	1.2E-006
	Copper ion binding	5	1.8E-003
2	Nucleolus	4	4.0E-003
3	Negative regulator of cell proliferation	4	8.6E-003
4	GTPase regulator activity	7	4.4E-003