FIGURE 2.

Sequence alignment of the core deacetylase domains of human SIRT1–7. The included sequences are SIRT1-207-573 (full-length, 747 a.a.), SIRT2-46-376 (389 a.a.), SIRT3-110-395 (399 a.a.), SIRT4-36-310 (314 a.a.), SIRT5-31-301 (310 a.a.), SIRT6-17-338 (355 a.a.), and SIRT7-67-377 (400 a.a.). The conserved residues are colored in red, and the functionally conserved residues are colored in green. Based on the crystal structures of SIRT2, -3, and -5, the α-helical regions are in red boxes, the β-sheets are underlined with solid lines, and the turn regions are underlined by dashed lines. The residues discussed under “Results and Discussion” are pointed by ▾ above the residues and labeled with the SIRT3 sequence number. The SIRT2 and SIRT5 insertion loops discussed under “Results and Discussion” are labeled. The alignment was done by T-Coffee (90).