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Mechanistic scheme of OatWY polysialic acid acetyltransferase. In the schematic above, the two interacting subunits, which define a complete active site, are represented as gray boxes and serve to illustrate the conformational role of Tyr-171 in allowing access to substrate acetyl-CoA. In the dotted box below, a proposed mechanistic scheme is shown highlighting the role of His-121 from one subunit and Trp-145′ from the second subunit that make up the active site.
