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The PDZ ligands of PKD1 and PKD2 bind to the first PDZ domain of the scaffold NHERF-1. The last 25 residues of PKD1 or PKD2 were fused to GST (GST-PKD1-CT and GST-PKD2-CT, respectively), and the purified fusion proteins were overlaid onto a proteomic array containing 96 PDZ domains. Binding to domains on the overlay was detected with an anti-GST antibody. The purified domain(s) on each spot of the array is listed.
