Fig. 2.

Underlying PK and AE relationships. a Underlying PK relationships—AUC mean by dose. The maximal predetermined mean exposure is 256 AUC. Dotted lines indicate lower and upper exposure targets (32 AUC and 128 AUC). b Underlying safety and toxicity/dose relationships—probability of AE by dose. Dotted lines indicate true underlying AE rate targets of 10% and 30%