Table I.

ANOVA Results for Comparing Designs at each Distribution (AUC = 128 for Maximal Efficacious Dose)

PK Pause	Target	Distribution	Metric	ANOVA results
Yes	PK	Proportional	Bias	A1<A4∼∼A2∼∼C2∼∼A5∼c3∼C1
			MSE	A5<C1∼∼A4∼A2<C2<A1<A3
		Saturated	Bias	A3∼A1<C2<C1<A4∼A2<A5
			MSE	A5<C1∼A2∼A4<C2<A1∼A3
		Steep	Bias	A1∼∼A3∼c2∼∼∼A2∼∼A4∼c1>A5
			MSE	A5<A2∼A4∼C1<C2∼∼A3∼A1
	Safety and tolerability	E max-like	Bias	C1<C2<A3∼∼A5∼A1<A2∼A4
			MSE	C1<C2∼A3∼A1∼A5<A2∼A4
		Log-Linear	Bias	C2<C1∼A2∼A5<A4<A3<A1
			MSE	C1∼C2<A5<A2<A4<A3<A1
		Logit	Bias	A5<A4∼A2<C1<c2<A1∼A3
			MSE	A5<C1<A2∼∼C2∼A4<A1<A3
No	PK	Proportional	Bias	A1<A2∼A4∼C2<A5∼C1<A3
			MSE	C1∼A5<C2∼∼A2∼∼A4∼A1<A3
		Saturated	Bias	A1<A3∼c2<C1∼∼A4∼A2<A5
			MSE	A4∼∼∼∼∼A2∼∼∼∼A5∼∼∼A1∼∼C2∼C1<A3
		Steep	Bias	A1∼∼A2∼∼A4∼C2∼A5∼C1<A3
			MSE	A5∼C1∼∼A4∼∼∼A2∼∼C2∼A1<A3
	Safety and tolerability	E max-like	Bias	C1<C2<A3∼∼A1∼A5<A2∼A4
			MSE	C1<C2∼∼A3∼A1<A5<A2∼A4
		Log-linear	Bias	C1<A5∼C2<A4∼A2<A1∼A3
			MSE	C1<C2∼A5<A4∼∼A1∼A2<A3
		Logit	Bias	A5<A4∼A2<C1∼C2<A3∼A1
			MSE	A5<C1<A2∼∼A4∼C2<A1∼A3

The designs are listed in increasing order of mean normalized rank. Statistically significant differences are indicated by "<" meaning that a design with "<" to its right is statistically significantly different from all designs to its right. A design with "∼" to its right is not statistically significantly different from the design immediately to its right. The number of "∼" symbols indicates how many designs to the right are not significantly different from the design at the left of those symbols