Table I.

Statistical Analysis of Diffusion/Dissolution Release Profiles of Budesonide from Different Formulations in Different Media (Each Formulation n = 5)

Constant	Reference	Test	Difference (f 1) (>15 indicates difference)	Similarity (f 2) (>50 indicates similarity)
Amorphous	Phosphate buffer	Simulated lung fluid	3.76	72.74
Crystalline	Phosphate buffer	Simulated lung fluid	8.69	55.85
Solid lipid microparticles	Phosphate buffer	Simulated lung fluid	10.77	58.85
Phosphate buffer	Amorphous	Crystalline	5.169	65.77
Phosphate buffer	Amorphous	Solid lipid microparticles	50.41a	28.13a
Phosphate buffer	Crystalline	Solid lipid microparticles	30.30a	31.44a
Simulated lung fluid	Amorphous	Crystalline	1.55	85.91
Simulated lung fluid	Amorphous	Solid lipid microparticles	44.24a	29.36a
Simulated lung fluid	Crystalline	Solid lipid microparticles	30.72a	29.37a

^a f ₁ > 15 and f ₂ < 50 suggest statistical differences