Table 1. Comparative analysis of pathways enriched in composite profiles of REST, CoREST and REST-CoREST target genes.

Ingenuity Canonical Pathway	REST	CoREST	REST-CoREST
Hypoxia Signaling in the Cardiovascular System	3.36
Estrogen Receptor Signaling	2.49	3.07
Protein Ubiquitination Pathway		2.44	2.17
CCR3 Signaling in Eosinophils		3.36
IL-8 Signaling		3.23
CXCR4 Signaling		3.16
fMLP Signaling in Neutrophils		2.88
LPS-stimulated MAPK Signaling		2.63
Macropinocytosis		2.45
CD28 Signaling in T Helper Cells		2.43
Role of NFAT in Regulation of the Immune Response		2.41
Chemokine Signaling		2.41
T Cell Receptor Signaling		2.39
Ephrin Receptor Signaling		2.35
Cardiac Hypertrophy Signaling		2.27
Thrombin Signaling		2.25
Glucocorticoid Receptor Signaling		2.23
Renin-Angiotensin Signaling		2.04
Huntington's Disease Signaling		2.03
Tight Junction Signaling			2.68
Induction of Apoptosis by HIV1			2.33
PTEN Signaling			2.17
Neuregulin Signaling			2.15

The values in each row represent the degree of pathway enrichment (–LogP) for each set of target genes. Only pathways exhibiting high statistical significance (–LogP>2) are included. Target genes were analyzed using Ingenuity Pathways Analysis (Ingenuity® Systems, www.ingenuity.com).