Table 1. Comparative analysis of pathways enriched in composite profiles of REST, CoREST and REST-CoREST target genes.
Ingenuity Canonical Pathway | REST | CoREST | REST-CoREST |
Hypoxia Signaling in the Cardiovascular System | 3.36 | ||
Estrogen Receptor Signaling | 2.49 | 3.07 | |
Protein Ubiquitination Pathway | 2.44 | 2.17 | |
CCR3 Signaling in Eosinophils | 3.36 | ||
IL-8 Signaling | 3.23 | ||
CXCR4 Signaling | 3.16 | ||
fMLP Signaling in Neutrophils | 2.88 | ||
LPS-stimulated MAPK Signaling | 2.63 | ||
Macropinocytosis | 2.45 | ||
CD28 Signaling in T Helper Cells | 2.43 | ||
Role of NFAT in Regulation of the Immune Response | 2.41 | ||
Chemokine Signaling | 2.41 | ||
T Cell Receptor Signaling | 2.39 | ||
Ephrin Receptor Signaling | 2.35 | ||
Cardiac Hypertrophy Signaling | 2.27 | ||
Thrombin Signaling | 2.25 | ||
Glucocorticoid Receptor Signaling | 2.23 | ||
Renin-Angiotensin Signaling | 2.04 | ||
Huntington's Disease Signaling | 2.03 | ||
Tight Junction Signaling | 2.68 | ||
Induction of Apoptosis by HIV1 | 2.33 | ||
PTEN Signaling | 2.17 | ||
Neuregulin Signaling | 2.15 |
The values in each row represent the degree of pathway enrichment (–LogP) for each set of target genes. Only pathways exhibiting high statistical significance (–LogP>2) are included. Target genes were analyzed using Ingenuity Pathways Analysis (Ingenuity® Systems, www.ingenuity.com).