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Mutations at the C-terminus of GlcCerase. Imiglucerase and pr-GlcCerase contain a His at residue 495 (yellow), whereas velaglucerase alfa contains Arg (green). Mutations R496 and D474, which cause Gaucher disease, are shown in magenta. Residues within 4 Å distance of R495 and R496 are shown in cyan.
