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. 2009 Aug 25;101(Pt 11):645–659. doi: 10.1042/BC20090042

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© 2009 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(A) Lineage illustration of notochord. (B) Tail-bud embryos co-injected with the lineage tracer and control FS Wnt5α mRNA into the A7.3 blastomere. (C) Injection of Wnt5α mRNA. Arrows indicate normally intercalated notochord cells. Arrowheads show cells that failed to intercalate. (D) Closer view of the blue rectangle in (C). Three notochord cells successfully intercalated. (E) Closer view of the red rectangle in (C). The two cells marked with arrowheads failed to intercalate with each other. (F–I) Four examples of Wnt5α mRNA-injected embryos to show the wide spectrum of abnormality in intercalation. In (I), post-convergent elongation of notochord cells is taking place. Scale bar, 100 μm.